(AP) -- Jeff Keppinger's one-out double in the 11th inning sent Cincinnati to a 4-3 victory over San Diego on Tuesday night in a rare loss for the Padres against the Reds when Jake Peavy started.

Jay Bruce started the rally with a one-out single off right-hander Bryan Corey (1-3). Keppinger doubled into the left-field corner for Cincinnati's 10th walkoff win, most in the majors.

Gary Majewski (1-0), the fifth Cincinnati pitcher. retired the three batters he faced in the 11th, getting the victory in a game full of empty swings. The Padres struck out 18 times, the Reds 13.

San Diego's Edgar Gonzalez had three hits, including an RBI single off Johnny Cueto, for his sixth straight multihit game. The rookie second baseman is 14-for-27 during his six-game hitting streak.

Peavy, the reigning Cy Young winner, is 6-0 in nine career starts against the Reds with a 2.31 ERA.