Carlos Santana hit a two-run homer in the eighth inning and the Cleveland Indians rallied past Seattle 5-4 Saturday, the Mariners' sixth straight loss.
Santana tagged Connor Sadzeck (0-1) for his fifth home run of the season.
Tim Beckham hit a leadoff home run to break a 3-all tie in the eighth - Seattle's fourth solo homer of the game. Edwin Encarnacion, Daniel Vogelbach and Dylan Moore also connected for Seattle, which leads the AL with 65 home runs.
Tyler Olson (1-0) retired the final hitter in the eighth for the win. Brad Hand walked Encarnacion to begin the ninth, then struck out the next three hitters for his 10th save.
Carlos Carrasco allowed all four home runs, a career high for the right-hander, who struck out nine in 7 2/3 innings.
Francisco Lindor singled to lead off the eighth against Roenis Elias and took second on Leonys Martin's sacrifice. Jose Ramirez struck out and Seattle manager Scott Servais went to Sadzeck, a rookie right-hander.
Santana quickly foiled that strategy and the Indians won for the second straight game in their final at-bat.
Cleveland played its second game since Corey Kluber broke his right arm after being hit by a line drive. Shane Bieber allowed one runs in 7 2/3 innings Friday.
Mariners starter Mike Leake allowed three runs in six innings. Seattle is 5-15 since starting the season with a 13-2 record.
Both teams scored in the second. Encarnacion hit a leadoff homer and Jake Bauers' RBI single tied the game.
Encarnacion played the last two seasons with Cleveland before being dealt to Seattle in a three-team trade that included Tampa Bay. The Indians acquired Santana, who was traded from Philadephia to Seattle earlier in the offseason.
Lindor's leadoff homer in the third gave Cleveland the lead. Vogelbach led off the fourth with a home run.
Roberto Perez's RBI single put Cleveland ahead in the fourth, but Moore, who played third base in place of the injured Ryon Healy, homered with two outs in the fifth.
Mariners: Healy was out of the lineup after leaving Friday's game with groin tightness.
Indians: RHP Danny Salazar has been shut down from throwing at extended spring training. He had progressed to throwing bullpen sessions after having shoulder surgery in July. Salazar missed all of last season.
The series ends Sunday when Erik Swanson starts for the Mariners against Cody Anderson in a matchup of right-handers. Swanson (0-3, 6.62 ERA) will make his fourth career start. Anderson will be recalled from Triple-A Columbus to make his first start in the majors since Sept. 14, 2016. He missed most of the last two seasons after having Tommy John surgery.
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