Teyvion Kirk's banked 3-pointer with 46 seconds provided the winning points after Ohio blew a 19-point second-half lead and the Bobcats beat Detroit Mercy 63-61 on Saturday.
Both teams missed two free throws each before Harrison Curry's 3-point try missed at the buzzer.
Kirk finished with 16 points and seven rebounds but committed eight turnovers. Jason Carter scored 20 points while Doug Taylor had 13 rebounds to go with nine points for Ohio (7-3).
A 12-0 run capped by a 3-pointer by Ben Vander Plas gave Ohio a 19-point lead with 12:21 to go. But Detroit responded with a 24-6 run led by eight points from Curry and seven by Antoine Davis while Ohio was going 2 of 11 as the Titans closed to within a point with three minutes left.
Davis, a freshman who came in as the nation's second-leading scorer at 27.4 per game and the 3-point leader at 5.4 per outing, finished with 19 points, making 3 of 11 from the arc for the Titans (3-8), who have lost five straight. Curry scored 12 points.
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