Colin Moran hit a three-run home run and finished with four RBIs, and Joe Musgrove beat his hometown Padres for the second time in as many seasons as the Pittsburgh Pirates won 6-4 Sunday to take three of four.
Musgrove (3-4) was the second straight alum of Grossmont High in suburban El Cajon to beat the Padres. Steven Brault won Saturday night in relief of opener Montana DuRapau.
The big right-hander took a one-hit shutout into the seventh before the Padres broke out for four runs, the big blow coming on Hunter Renfroe's three-run home run.
Greg Garcia, who played at Valhalla High in El Cajon, was the first Padres baserunner to reach second against Musgrove when he hit a leadoff double. He scored on a single by Alex Dickerson, who played at suburban Poway High.
With one out, Eric Hosmer hit a comebacker and Musgrove tried to go to second but his throw was wide for an error. Renfroe followed with a shot into the Padres' bullpen beyond the left-center fence to pull the Padres to 5-4. It was his 11th homer.
Moran got his fourth RBI in the eighth when he drove in Bryan Reynolds, who doubled.
Musgrove retired his first six batters and didn't allow a hit until Hosmer singled to left leading off the fifth. He allowed four runs, three earned, and four hits in 6 1/3 innings, with four strikeouts and one walk.
Felipe Vazquez pitched the ninth for his 13th save.
Moran's homer off rookie Cal Quantrill (0-2) with two outs in the first inning helped stake Musgrove to a 4-0 lead before he threw a pitch and was Pittsburgh's fourth hit in a span of six batters. Josh Bell, who homered twice in Saturday night's win, was aboard on an RBI single and rookie Reynolds, who homered Friday and Saturday nights, also singled ahead of Moran's homer.
Moran added an RBI single in the eighth off Robbie Erlin.
Quantrill was recalled from Triple-A El Paso to make the spot start, his third this season. He allowed five runs and eight hits in five innings, struck out two and walked two.
Pirates: RHP Chris Archer (1-3, 5.58) is scheduled to start Tuesday night in the opener of a three-game home series against Colorado.
Padres: Rookie RHP Chris Paddack (3-2, 1.99) is scheduled to start the opener of a three-game home series against Arizona on Monday night. He's coming off his worst start, when he allowed season highs with five hits and six runs, although only three were earned.
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